Microdialysis measures these extracellular substances to continuously gauge the biochemistry of neurons and glia and to determine how seriously brain cells are impaired after ischemia, hyperemia, trauma or hemorrhage. This data and analysis may predict outcome in SAH, TBI and stroke patients and can serve as one of the tools used to individualize patient management in the neurointensive care unit. In the future, clinical microdialysis may be utilized to deliver drugs or substances to the brain, as well as to continuously analyze neurotransmitters, cytokines and small proteins.
“Microdialysis allows us to examine changes on a cellular and metabolic level after ischemia in a safe and effective manner,” says Alois Zauner, MD, general and cerebrovascular neurosurgeon and neuroendovascular and neurointerventional surgeon on the medical staff of Santa Barbara Neuroscience Institute at Cottage Health System. “It also advances indications of increasing intracranial pressure by about 48 hours and allows us to better titrate treatments for patients.”
Capturing Data for Evaluation and Treatment
To optimally employ microdialysis, physicians at Santa Barbara Neuroscience Institute at Cottage Health System work with a highly specialized nursing staff to provide continuous bedside monitoring and manage microdialysis equipment.
Microdialysis requires the evaluation of multimodal data with varying ranges for pathology, combined with storing data on an advanced IT system.