Tigecycline Injection
Brand Name(s):
  • Tygacil®
IMPORTANT WARNING
In clinical studies, more patients who were treated with tigecycline injection for serious infections died than patients who were treated with other medications for serious infections. These people died because their infections worsened, because they developed complications of their infections, or because of other medical conditions they had. There is not enough information to tell whether using tigecycline injection increases the risk of death during treatment. Your doctor will only treat you with tigecycline injection if other medication cannot be used to treat your infection.

Talk to your doctor about the risk of using tigecycline injection.

WHY is this medicine prescribed?
Tigecycline injection used to treat certain serious infections including community acquired pneumonia (a lung infection that developed in a person who was not in the hospital), skin infections, and infections of the abdomen (area between the chest and the waist). Tigecycline injection should not be used to treat pneumonia that developed in people who were in a hospital or foot infections in people who have diabetes. Tigecycline injection is in a class of antibiotics called tetracyclines. It works by killing bacteria that cause infection. Antibiotics will not work for colds, flu, or other viral infections.

HOW should this medicine be used?
Tigecycline injection comes as a powder to be mixed with fluid and injected into a vein. It is usually infused (injected slowly) intravenously (into a vein) over a period of 30 to 60 minutes, once every 12 hours. The length of your treatment depends on the type of infection you have and how your body responds to the medication.

You may receive tigecycline injection in a hospital or you may use the medication at home. Follow the directions on your prescription label carefully, and ask your doctor or other healthcare provider to explain any part you do not understand. Use tigecycline injection exactly as directed. Do not infuse it more quickly than directed. Do not use more or less of it or use it more often than prescribed by your doctor.

If you will be using tigecycline injection at home, your healthcare provider will show you how to infuse the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions. Ask your healthcare provider what to do if you have any problems infusing tigecycline injection.

You should begin to feel better during the first few days of treatment with tigecycline injection. If your symptoms do not improve or get worse, call your doctor.

Use tigecycline injection until you finish the prescription, even if you feel better. If you stop using tigecycline injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Are there OTHER USES for this medicine?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?
Before using tigecycline injection,

  • tell your doctor and pharmacist if you are allergic to tigecycline injection; other tetracycline antibiotics such as doxycycline (Monodox, Oracea, Vibramcyin), minocycline (Dynacin, Minocin, Solodyn), and tetracycline (in Helidac, in Pylera); any other medications, or any of the ingredients in tigecycline injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); or oral contraceptives (birth control pills). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using tigecycline injection, call your doctor.
  • plan to avoid unnecessary or prolonged exposure to sunlight or ultraviolet light (tanning beds and sunlamps) and to wear protective clothing, sunglasses, and sunscreen. Tigecycline injection may make your skin sensitive to sunlight or ultraviolet light.
  • you should know that when tigecycline injection is used during pregnancy or in babies or children up to age 8, it can cause the teeth to become permanently stained. Tigecycline should not be used in children under age 8 unless your doctor decides it is needed.
What SPECIAL DIETARY instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?
Infuse the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not use a double dose to make up for a missed one.

What SIDE EFFECTS can this medicine cause?
Tigecycline injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • nausea
  • vomiting
  • stomach pain
  • heartburn
  • loss of appetite
  • headache
  • weakness
  • dizziness

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical help:
  • severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment)
  • blistering or peeling skin
  • rash
  • hives
  • tingling or swelling of the face, neck, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • difficulty breathing or swallowing
  • itching
  • yellowing of the skin or eyes
  • sore throat, fever, chills, and other signs of new or worsening infection

Tigecycline injection may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at Web Site] or by phone [1-800-332-1088].

What should I know about STORAGE and DISPOSAL of this medication?
Your healthcare provider will tell you how to store your medication. Store your medication only as directed. Make sure you understand how to store your medication properly. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

What should I do in case of OVERDOSE?
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:
  • nausea
  • vomiting

What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to tigecycline injection.

If you still have symptoms of infection after you finish tigecycline injection, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: January 15, 2014.







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