Cisapride is only available in the United States to special patients who are signed up by their doctors. Talk to your doctor or pharmacist about whether you should be taking cisapride.
Cisapride may cause serious irregular heart beats, which can lead to death. Tell your doctor if you have a family history of heart problems and if you have or have ever had irregular heart beats, heart disease, severe dehydration, vomiting, eating disorders, or kidney or lung failure.
Tell your doctor about all the prescription and nonprescription medications you are taking. Do not take cisapride if you are taking bepridil (Vascor); chlorpromazine (Thorazine); clarithromycin (Biaxin); erythromycin (E.E.S., E-Mycin, Ery-Tab); fluconazole (Diflucan); fluphenazine (Prolixin); itraconazole (Sporanox); ketoconazole (Nizoral); medications for depression such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), maprotiline (Ludiomil), nefazodone (Serzone), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); medications for irregular heart beats such as amiodarone (Cordarone), disopyramide (Norpace), quinidine (Quinidex), procainamide (Procanbid, Pronestyl), and sotalol (Betapace); mesoridazine (Serentil); perphenazine (Trilafon); prochlorperazine (Compazine); promethazine (Phenergan); protease inhibitors such as indinavir (Crixivan) and ritonavir (Norvir); sertindole (Serlect); sparfloxacin (Zagam); thioridazine (Mellaril); thiothixene (Navane); trifluoperazine (Stelazine); or troleandomycin (Tao). Do not drink grapefruit juice while taking cisapride.
Do not take more of cisapride or take it more often than prescibed by your doctor. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to cisapride.
If you experience either of the following symptoms, call your doctor immediately: fainting or irregular or fast heartbeats.
Cisapride is used to treat symptoms of nighttime heartburn in people who have not responded to other treatments.
Cisapride comes as a tablet and liquid to take by mouth. Cisapride usually is taken four times a day, 15 minutes before meals and at bedtime. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cisapride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
This medication should not be prescribed for other uses; ask your doctor or pharmacist for more information.
Before taking cisapride,
- tell your doctor and pharmacist if you are allergic to cisapride or any other drugs.
- in addition to the medications listed in the IMPORTANT WARNING section, tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antianxiety medications, anticholinergics (atropine, belladonna, benztropine, dicyclomine, diphenhydramine, isopropamide, procyclidine, and scopolamine), anticoagulants ('blood thinners') such as warfarin (Coumadin), azithromycin (Zithromax), cimetidine (Tagamet), dirithromycin (Dynabac), diuretics ('water pills'), miconazole (Monistat), tranquilizers, and vitamins.
- tell your doctor if you have or have ever had intestinal disorders or bleeding ulcers.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking cisapride, call your doctor.
- you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
- remember that alcohol can add to the drowsiness caused by this drug.
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Cisapride may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- upset stomach
- stomach discomfort
- stuffy nose
If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section call your doctor immediately: If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at Web Site] or by phone [1-800-332-1088].
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to cisapride.
Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Last Reviewed: September 1, 2010.