Lubiprostone is used to relieve stomach pain, bloating, and straining and produce softer and more frequent bowel movements in people who have chronic idiopathic constipation (difficult or infrequent passage of stools that lasts for 3 months or longer and is not caused by a disease or a medication).. Lubiprostone is also used to treat irritable bowel syndrome with constipation (IBS-C; a condition that causes stomach pain or cramps, bloating, and infrequent or difficult passage of stools) in women who are at least 18 years of age. Lubiprostone is in a class of medications called laxatives. It works by increasing the amount of fluid that flows into the bowel and allowing the stool to pass more easily.
Lubiprostone comes as a capsule to take by mouth. It is usually taken with food twice a day in the morning and evening. Take lubiprostone at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lubiprostone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the capsule whole; do not open, chew, or crush it. Tell your doctor if you are unable to swallow the capsule.
Lubiprostone may help to relieve your symptoms, but will not cure your condition. Continue to take lubiprostone even if you feel well. Do not stop taking lubiprostone without talking to your doctor. Your doctor will monitor your condition and will tell you when you should stop taking lubiprostone.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before taking lubiprostone,
- tell your doctor and pharmacist if you are allergic to lubiprostone or any other medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
- tell your doctor if you have or have ever had a blockage in your stomach or bowels. If you do not know if you have a blockage in your stomach or bowels, your doctor will examine you to see whether you have this condition. If you have this type of blockage, your doctor will probably tell you not to take lubiprostone.
- tell your doctor if you have severe diarrhea or kidney or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You will need to have a negative pregnancy test before you begin to take lubiprostone. You must use birth control while taking this medication. Talk to your doctor about the method of birth control that is best for you. If you become pregnant while taking lubiprostone, call your doctor right away.
Unless your doctor tells you otherwise, continue your normal diet.
Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Lubiprostone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- stomach pain or bloating
- swelling of the hands, feet, ankles, or lower legs
- discomfort in chest
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
- shortness of breath
- swelling of the face, lips, mouth, tongue or throat
- tightness in throat
Lubiprostone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at Web Site] or by phone [1-800-332-1088].
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
- stomach pain
- shortness of breath
- pale skin
- loss of appetite
- chest discomfort
- dry mouth
- excessive sweating
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
AHFS® Consumer Medication Information. © Copyright, The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Last Reviewed: September 1, 2010.