Occupation and Cancer RiskEn Español (Spanish Version)
Unfortunately, it is not always easy to establish a link between occupation and cancer risk. A small percentage of chemicals used in commerce have been tested for their potential to cause cancer. It is estimated that between 4%-10% of cancers in the United States are caused by occupational exposure. But, the risk of developing cancer is influenced by a number of factors that are not clearly understood. Read on to find out more.
According to the National Institute for Occupation Health and Safety (NIOSH), a person’s risk for developing cancer may be influenced by a combination of the following factors:
Personal characteristics (eg, age, sex, race)
- Family history of cancer
Lifestyle factors and personal habits (eg, diet, smoking, alcohol consumption)
- Certain medical conditions
- Exposure to cancer-causing agents in the environment
- Exposure to cancer-causing agents in the workplace
These factors may act together or in sequence to cause cancer.
Sometimes, a number of people in a workplace will develop cancer within a relatively short period of time. However, this does not necessarily indicate that there is a cancer risk in the workplace. Cancer is a common disease, affecting over a million Americans each year.
In an effort to identify the role of possible occupational factors and cancer, scientists investigate cancer clusters. Clusters are defined as an unusual concentration of cancer cases in a defined area or time, according to NIOSH. Clusters may have a common cause or may be the coincidental occurrence of unrelated causes.
When evaluating a cancer cluster in the workplace, scientists tend to look for the following:
- Several cases of the same type of cancer, especially if it is not common in the general population
- The presence of a known or suspected cancer-causing agent, and, the occurrence of types of cancers that have been linked with exposures to these agents in other settings
- Past exposures to possible cancer-causing agents in the workplace (often difficult to document)
Investigating cancer clusters poses many challenges for researchers. It is often difficult to make a clear connection between cancer and environmental or workplace factors.
CancerSubstances or ProcessesLung
Arsenic, asbestos, cadmium, coke oven fumes, chromium compounds, coal gasification, nickel refining, foundry substances, radon, soot, tars, oils, silicaBladder
Aluminum production, rubber industry, leather industry, 4-aminobiphenyl, benzidineNasal cavities and sinusesFormaldehyde, isopropyl alcohol manufacture, mustard gas, nickel refining, leather dust, wood dustLarynxAsbestos, isopropyl alcohol, mustard gasPharynxFormaldehyde, mustard gasMesothelioma (type of lung cancer)AsbestosLymphatic and hematopoietic (blood cell producing) systemBenzene, ethylene oxide, herbicides, x-radiation systemSkinArsenic, coal tars, mineral oils, sunlightSoft-tissue sarcoma
Chlorophenols, chlorophenoxy herbicidesLiver
Arsenic, vinyl chlorideLipSunlight
Identifying occupational risks for cancer is an ongoing process. Since it is often difficult to know if we are being exposed to cancer risks in the workplace, the best we can do is use the knowledge already at hand, and control the risk factors that we know we can control.
For example, we are largely in control of diet, smoking, alcohol use, and exposure to known cancer-causing agents. We can also get regular medical check-ups and follow the national guidelines regarding cancer screening tests.
International Agency for Research on Cancer
The National Institute for Occupational Health and Safety
Occupational Safety and Health Administration
American Cancer Society. Occupation and cancer. American Cancer Society website. Available at: http://www.cancer.org/downloads/PRO/occupation.pdf. Published 2006. Accessed June 12, 2012.
Occupational cancer. Centers for Disease Control and Prevention, National Institute for Occupational Health and Safety website. Available at:
http://www.cdc.gov/niosh/topics/cancer/. Updated February 2, 2012. Accessed on June 12, 2012.
Cancer causes and risk factors.
National Cancer Institute website. Available at:
. Accessed on June 12, 2012.
Last Reviewed June 2012