Fibrate Drugs
  • B Vitamins - Possible Helpful Interaction
  • Blood Thinning Supplements - Possible Harmful Interaction
En Español (Spanish Version)

Drugs in the fibrate family are used to improve levels of cholesterol and related lipids found in the blood. Fibrates are particularly helpful for individuals with high levels of triglycerides.

Medications in this category include:


  • Clofibrate (Atromid-S)
  • Gemfibrozil (Lopid)
  • Fenofibrate (Tricor)
B Vitamins
Possible Helpful Interaction
Fibrate drugs are known to raise homocysteine levels in the blood. High levels of homocycsteine have been associated with increased risk of heart disease, although a direct connection has not been proven.


In a double-blind, placebo controlled trial of 29 men taking fenofibrate, use of the B-vitamins folate (650mcg), vitamin B12 (50mcg) and vitamin B6 (50mg) once daily for 6 weeks restored homocysteine levels to nearly normal values. 1

Blood Thinning Supplements
Possible Harmful Interaction
Fibrate drugs are known to increase the "blood thinning" effects of drugs in the warfarin (Coumadin) family. Certain herbs, such as garlic, danshen, devil’s claw, dong quai, papaya, PC-SPES and red clover, may thin the blood in a manner somewhat similar to warfarin. Although no such interactions have yet been reported, it is at least theoretically possible that combined use of these herbs and fibrate drugs could pose a risk of bleeding problems.




Dierkes J, Westphal S, Kunstmann S, et al. Vitamin supplementation can markedly reduce the homocysteine elevation induced by fenofibrate. Atherosclerosis . 2001;158:161-164.
Last Reviewed August 2013



Health Information Library content is provided by EBSCO Publishing, fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.

 

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

 

To send comments or feedback to EBSCO's Editorial Team regarding the content please e-mail healthlibrarysupport@ebscohost.com.