Calcium Channel Blockers
  • Calcium and Vitamin D —Possible Decreased Action of Drug
  • Ginkgo Biloba —Possible Decreased Action of Drug
  • Naringen (a Citrus Bioflavonoid)—May Necessitate Reduction of Drug Dosage
En Español (Spanish Version)

Calcium channel–blockers are used to treat hypertension , angina , heart arrhythmias , and other heart-related conditions.

Examples of drugs in this family include:
  • Amlodipine (Norvasc)
  • Bepridil hydrochloride (Vascor)
  • Diltiazem (Cardizem, Cardizem CD, Cardizem SR, Dilacor XR, Tiamate, Tiazac)
  • Felodipine (Plendil)
  • Isradipine (DynaCirc, DynaCirc CR)
  • Nicardipine hydrochloride (Cardene, Cardene SR)
  • Nifedipine (Procardia, Procardia XL, Adalat, Adalat CC)
  • Nimodipine (Nimotop)
  • Nisoldipine (Sular)
  • Verapamil (Calan, Calan SR, Covera-HS, Isoptin, Isoptin SR, Verelan)

Possible Decreased Action of Drug
Taking calcium and vitamin D supplements might interfere with some of the effects of calcium channel-blockers. 1-7

Ginkgo Biloba

Possible Decreased Action of Drug
According to a study in rats, ginkgo extract may cause the body to metabolize some calcium channel blockers more rapidly, thereby decreasing their effects. 8

Naringen (a Citrus Bioflavonoid )
May Necessitate Reduction in Drug Dosage
Some evidence suggests that the bioflavonoid naringen may interact with medications in the calcium channel blocker family, increasing blood levels of the drug. 9 This may necessitate a reduction in drug dosage.




Bar-Or D and Gasiel Y. Calcium and calciferol antagonise effect of verapamil in atrial fibrillation. Br Med J (Clin Res Ed) . 1981;282:1585-1586. Hariman RJ, Mangiardi LM, McAllister RG Jr, et al. Reversal of the cardiovascular effects of verapamil by calcium and sodium: differences between electrophysiologic and hemodynamic responses. Circulation . 1971;59:797-804. Guadagnino V, Greengart A, Hollander G, et al. Treatment of severe left ventricular dysfunction with calcium chloride in patients receiving verapamil. J Clin Pharmacol. 1987;27:407-409. Salerno DM, Anderson B, Sharkey PJ, et al. Intravenous verapamil for treatment of multifocal atrial tachycardia with and without calcium pretreatment. Ann Intern Med. 1987;107:623-628. Luscher TF, Noll G, Sturmer T, et al. Calcium gluconate in severe verapamil intoxication. N Engl J Med. 1994;330:718-720. Orr GM, Bodansky HJ, Dymond DS, et al. Fatal verapamil overdose. Lancet. 1982;2:1218-1219. Kuhn M and Schriger DL. Low-dose calcium pretreatment to prevent verapamil-induced hypotension. Am Heart J. 1992;124:231-232. Shinozuka K, Umegaki K, Kubota Y, et al. Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats. Life Sci. 2002;70:2783-2792. Yeum CH, Choi JS. Effect of naringin pretreatment on bioavailability of verapamil in rabbits. Arch Pharm Res. 2006;29:102-107.
Last Reviewed August 2013



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