Calcium Channel Blockers
- Calcium and Vitamin D
—Possible Decreased Action of Drug
- Ginkgo Biloba
—Possible Decreased Action of Drug
- Naringen
(a Citrus Bioflavonoid)—May Necessitate Reduction of Drug Dosage
En Español (Spanish Version)
Examples of drugs in this family include:
- Amlodipine (Norvasc)
- Bepridil hydrochloride (Vascor)
- Diltiazem (Cardizem, Cardizem CD, Cardizem SR, Dilacor XR, Tiamate, Tiazac)
- Felodipine (Plendil)
- Isradipine (DynaCirc, DynaCirc CR)
- Nicardipine hydrochloride (Cardene, Cardene SR)
- Nifedipine (Procardia, Procardia XL, Adalat, Adalat CC)
- Nimodipine (Nimotop)
- Nisoldipine (Sular)
- Verapamil (Calan, Calan SR, Covera-HS, Isoptin, Isoptin SR, Verelan)
Possible Decreased Action of Drug
Taking calcium and vitamin D supplements might interfere with some of the effects of calcium channel-blockers.
1-7
Ginkgo Biloba
Possible Decreased Action of Drug
According to a study in rats, ginkgo extract may cause the body to metabolize some calcium channel blockers more rapidly, thereby decreasing their effects.
8
May Necessitate Reduction in Drug Dosage
Some evidence suggests that the bioflavonoid naringen may interact with medications in the calcium channel blocker family, increasing blood levels of the drug.
9
This may necessitate a reduction in drug dosage.
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.
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Ginkgo biloba
extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats.
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2002;70:2783-2792.
Yeum CH, Choi JS. Effect of naringin pretreatment on bioavailability of verapamil in rabbits.
Arch Pharm Res.
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Last Reviewed July 2012