Aldesleukin
The following information is an educational aid only. It is not intended as a medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

Aldesleukin
(al des LOO kin)

U.S. Brand Names
Proleukin®

Canadian Brand Names
Proleukin®

Pharmacologic Category
Antineoplastic Agent, Miscellaneous; Biological Response Modulator

What key warnings should I know about before taking this medicine?
This medicine is very strong. It may cause severe low blood pressure and damage to your organs. Tell healthcare provider if you have any heart or lung disease. Serious infections may occur following use of this medicine. Tell healthcare provider right away if you feel extremely sleepy or weak.

Closely review the section in this leaflet which lists when to call healthcare provider. You will be closely monitored by healthcare provider.

Reasons not to take this medicine
• If you have an allergy to aldesleukin or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you have any of the following conditions: Bleeding from the stomach or intestines, coma, dialysis, fast heartbeat, heart disease, hole in the gastrointestinal tract, lung disease, organ transplant, or seizures.

• If you are breast-feeding.

What is this medicine used for?
• This medicine is used to treat a variety of cancers.

How does it work?
• Aldesleukin helps the body's immune system fight cancer.

How is it best taken?
• This medicine is given as a shot into the fatty part of the skin.

• This medicine is given into a vein constantly for a period of time.

• Drink plenty of noncaffeine-containing liquid unless told to drink less liquid by healthcare provider.

What do I do if I miss a dose? (does not apply to patients in the hospital)
• Call healthcare provider for instructions.

What are the precautions when taking this medicine?
• Talk with healthcare provider before receiving any vaccinations. Use with this medicine may either increase the risk of serious infection or make the vaccination less effective.

• If you have kidney disease, talk with healthcare provider.

• If you have liver disease, talk with healthcare provider.

• If you are having an x-ray with dye, talk with healthcare provider.

• Check medicines with healthcare provider. This medicine may not mix well with other medicines.

• Avoid alcohol (includes wine, beer, and liquor) or other medicines and natural products that slow your actions and reactions. These include sedatives, tranquilizers, mood stabilizers, antihistamines, and other pain medicine.

• You may not be alert. Avoid driving, doing other tasks or activities until you see how this medicine affects you.

• Tell healthcare provider if you are pregnant or plan on getting pregnant.

What are some possible side effects of this medicine?
• Risk of infection. Avoid people with infections, colds, or flu.

• Feeling lightheaded, sleepy, having blurred vision, or a change in thinking clearly. Avoid driving, doing other tasks or activities that require you to be alert or have clear vision until you see how this medicine affects you.

• Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.

• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

• Diarrhea.

• Mouth irritation. Frequent mouth care with a soft toothbrush or cotton swabs and rinsing mouth may help.

• Weight gain.

• Feeling tired or weak.

• Anemia, low white blood cell count, and low platelet count. Medicine may need to be stopped.

What should I monitor?
• You will be monitored closely by healthcare provider.

Reasons to call healthcare provider immediately
• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Signs or symptoms of infection. These include a fever of 100.5 degrees or higher, chills, severe sore throat, ear or sinus pain, cough, increased sputum or change in color, painful urination, mouth sores, wound that will not heal, or anal itching or pain.

• Chest pain or pressure or fast heartbeat.

• Severe dizziness or passing out.

• Difficulty breathing.

• Significant change in thinking clearly and logically.

• Swelling of legs or belly.

• Significant weight gain.

• Severe belly pain.

• Unable to pass urine.

• Unusual bruising or bleeding.

• Yellow skin or eyes.

• Feeling extremely tired or weak.

• Any rash.

• No improvement in condition or feeling worse.

How should I store this medicine?
• This medicine will be given to you in a healthcare setting. You will not store it at home.

General statements
• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

Created: 2007-04-11 08:34:59.0

Modified: 2009-05-21 13:14:04.0

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