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Type 2 Diabetes
En Español (Spanish Version)
More InDepth Information on This Condition


Definition
Glucose comes from the breakdown of food. It is the body's energy source. It can be absorbed from the blood into the cells with the help of a hormone called insulin . Without insulin, glucose will build up in the blood and cause hyperglycemia. At the same time, your body's cells are starved for glucose (energy).

A lack of insulin or resistance to insulin causes diabetes. In type 2 diabetes, the body is resistant to high levels of insulin. There is plenty of insulin in the body, but the cells are unable to use it.

High blood sugar levels over a long period of time can damage vital organs. This can include the kidneys, eyes, and nerves.

The Pancreas

© 2011 Nucleus Medical Media, Inc.

Causes
Two conditions contribute to hyperglycemia in type 2 diabetes:

  • Insulin resistance related to excess body fat
  • Body's failure to make an adequate amount of insulin
Risk Factors
Factors that increase your chance for type 2 diabetes include:

  • Having a family history of type 2 diabetes
  • Being obese or overweight (especially excess weight in the upper body and abdomen)
  • Eating a lot of meat, especially processed meat (eg, processed luncheon meats, hot dogs, sausages)
  • Having cholesterol problems (low HDL "good" cholesterol and high triglycerides )
  • Having high blood pressure
  • Having a history of cardiovascular disease
  • Having depression
  • Having a history of gestational diabetes or having a baby that weighs over nine pounds
  • Having an endocrine disorder ( Cushing’s syndrome , hyperthyroidism , acromegaly , polycystic ovary syndrome , pheochromocytoma, glucagonoma)
  • Having a condition associated with insulin resistance (eg, acanthosis nigricans )
  • Having previous blood test results that show impaired glucose tolerance and impaired fasting glucose
  • Taking certain medicines (eg, pentamidine , nicotinic acid, glucocorticoids, thiazide)
  • Having a sedentary lifestyle
  • Having sleep difficulties
  • Having a low birth weight
  • Gender: more common in older women than men
  • Race: African American, Hispanic, Native American, Hispanic American, Asian American, or Pacific Islander
  • Age: 45 years or older and younger people who are obese and belong to at risk ethnic groups
Symptoms
You may not have symptoms for years. Symptoms due to high blood sugar or diabetic complications may include:

Diagnosis
The doctor will ask about your symptoms and medical history. You will also be asked about your family history. A physical exam will be done.

Diagnosis is based on the results of blood testing. These guidelines are from the American Diabetes Association (ADA):

  • Symptoms of diabetes and a random blood test revealing a blood sugar level greater than or equal to 200 mg/dL [11.1 mmol/L]
  • Blood sugar tests after you have not eaten for eight or more hours (called fasting blood sugar ) revealing blood sugar levels greater than or equal to 126 mg/dL (7.0 mmol/L) on two different days
  • Glucose tolerance test measuring blood sugar two hours after you consume glucose with a measurement greater than or equal to 200 mg/dL (11.1 mmol/L)
  • HbA1c level of 6.5% or higher, indicating poor blood sugar control over the past 2-4 months
mg/dL=milligrams per deciliter of blood; mmol/L=millimole per liter of blood

Treatment
Treatment aims to:

  • Maintain blood sugar at levels as close to normal as possible
  • Preventing or delaying complications (regular medical care is important for this)
  • Control other conditions that you may have, like high blood pressure and high cholesterol
Diet
Weight Loss
If you are overweight, talk to your doctor about a reasonable weight goal. Weight loss will help your body respond better to insulin. You and your doctor or nutritionist can develop a safe diet program for you.

There are options that may help you lose weight:

Group education may help people recently diagnosed with their goals in weight loss.

Exercise
Physical activity:

  • Can make the body become more sensitive to insulin
  • Will help you reach and maintain a healthy weight
  • Can lower the levels of fat in your blood
  • Has been found to improve blood sugar control— Aerobic exercise and strength training can help to improve HbA1c levels. Researchers have also found that long-term strength and endurance training may improve HbAIc, even in the absence of weight loss.
Talk to your doctor about any restrictions. Work with your doctor to make an activity plan. Even a brief counseling session may help to increase your activity levels.

Diabetes is a risk factor for heart disease. Exercising can help to reduce your risk for heart disease.

Oral Medication
Medicines taken by mouth may be used to lower blood sugar:

  • Metformin : a class of drug that reduces the body's production of glucose. It also makes the body more sensitive to insulin. This combination will help keep blood sugar levels within the normal limits.
  • Drugs that prompt the cells in the pancreas to make more insulin (eg, sulfonylureas [ glyburide , tolazamide ], dipeptidyl peptidase-4 inhibitors [ saxagliptin , sitagliptin ], repaglinide [Prandin], linagliptin [Tradjenta])
    • The FDA has warned that sitagliptin may increase the risk of acute pancreatitis.
  • Insulin sensitizers—a class of drugs that help the body better use insulin (eg, pioglitazone )
  • Starch blockers—a class of drugs (eg, acarbose , miglitol ) that lessen glucose absorption into the bloodstream
Injectable medicine, such as:

  • Incretin-mimetics (eg, exenatide ) stimulate the pancreas to produce insulin and suppress appetite often leading to weight loss (twice daily injections).
  • Amylin analogues (eg, pramlintide ) replace a protein that is normally produced by the pancreas and is low in people with type 2 diabetes (injection before each meal).
Insulin
In some cases the body does not make enough insulin. Insulin injections may be needed.

This is needed when blood sugar levels are not kept low enough with lifestyle change and medicine.

Blood Sugar Testing
Checking blood sugar levels during the day can help you stay on track. It will also helps your doctor determine if your treatment is working. Testing is easy with a monitor. Keeping track of blood sugar levels is especially important if you take insulin. Frequency of testing is determined by how well your blood sugar control is doing.

The HbA1c may also be done at your doctor's office. Doctors advise that most keep their HbA1c levels below 7% (ADA recommendation). This level has been shown to lead to fewer diabetic complications.

Regular blood sugar testing may not be needed in patients with type 2 diabetes. It may not be needed for those whose condition is under reasonably good control without insulin. Talk with your doctor before stopping blood sugar monitoring.

Alternative Therapies
One study focused on people with a specific type 2 diabetes. When given vitamin E, they showed a decrease in the rates of heart problems.

Prevention
Lifestyle changes seem to be most effective. To reduce your chances of developing type 2 diabetes:

  • Participate in regular physical activity.
  • Maintain a healthy weight.
  • Drink alcohol in moderation (two drinks per day for a man, and one drink per day for a woman)
  • Eat a well-balanced diet:
    • Get enough fiber
    • Avoid fatty foods
    • Limit sugar intake
    • Eat more green, leafy vegetables
BE = This therapy has the best evidence available showing that it is effective.



RESOURCES:
American Diabetes Association

National Diabetes Information Clearinghouse

CANADIAN RESOURCES:
Canadian Diabetes Association

Team Diabetes Canada
Canadian Diabetes Association

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1/4/2011 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Pan A, Lucas M, Sun Q, et al. Bidirectional association between depression and type 2 diabetes mellitus in women. Arch Intern Med. 2010;170(21):1884-1891.

5/6/2011 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : US Food and Drug Administration. FDA approves new treatment for Type 2 diabetes. US Food and Drug Administration website. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm253501.htm . Updated May 2, 2011. Accessed May 6, 2011.

Last Reviewed September 2011